Impairment of intestinal intraepithelial lymphocytes in Id2 deficient mice
نویسندگان
چکیده
منابع مشابه
Impairment of intestinal intraepithelial lymphocytes in Id2 deficient mice.
BACKGROUND Id2, an inhibitor of basic helix-loop-helix transcription factors, regulates cell differentiation. Id2-/- mice exhibit a variety of phenotypes in the immune system. AIMS In this study we investigated whether Id2 plays a role in intestinal intraepithelial lymphocytes (IELs), which constitute the main defence against pathogens in the intestinal tract. METHODS Flow cytometry and bon...
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The transmembrane protein tyrosine phosphatase CD45 is differentially required for the development and function of B, T, and NK cells, with mice partially deficient for CD45 having a significant inhibition of T cell, but not NK or B cell, development. CD45-mediated signaling has also been implicated in the development of intrathymic, but not extrathymic, intestinal intraepithelial T lymphocytes...
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ژورنال
عنوان ژورنال: Gut
سال: 2004
ISSN: 0017-5749
DOI: 10.1136/gut.2003.022293